One saliva sample, sequenced and interpreted against 700+ oral species, linking your oral bacteria to systemic disease risk, then signed by a clinician before you see it.
82/100
Overall Oral Health Score
Top recommendation
Floss daily and increase fiber-rich foods to reduce inflammation-associated bacteria.
Your report, in 48 hours
Sequenced by NovogeneAIT Genomics · Signed by an Orvana clinician
The clinical signal, the scale, and the opportunity
700+
Oral microbial species profiled
12
Disease-linked signatures tracked
48 hours
From swab to personalised report
3.5B
People worldwide affected by oral disease
90%
Systemic diseases with oral manifestations
$42B
Global oral diagnostics opportunity
78%
Projected gross margin by year 3
Built on the partners and platform behind every report
16S rRNA sequencing with Science Werks QC; research pathway with A*STAR IHDP.
Standard care is reactive. By the time oral disease is detected, systemic damage may already be underway, despite strong links between the oral microbiome, diabetes, cardiovascular disease, Alzheimer's, and inflammatory conditions.
Oral disease is common, but its systemic signals rarely become actionable clinical intelligence.
Existing tools do not provide clinical-scale oral microbiome profiling for Southeast Asian consumers.
The region has rising health awareness but underpenetrated preventive diagnostics.
Orvana sequences and analyses the full oral microbiome, delivering personalised health intelligence across Southeast Asia, starting with Singapore and scaling into Malaysia, Indonesia, and the Philippines.
NGS-based profiling of 700+ oral microbial species through certified lab partners.
Every Orvana test returns a personalised Oral Health Intelligence Report: clear, actionable, and useful for both consumers and clinicians.
Everything in your report, from your oral health score to personalised recommendations and progress tracking.
Oral health score
An easy-to-understand summary of your current oral microbiome health.
Cavity risk assessment
Understand microbial patterns associated with tooth decay and enamel damage.
Gum health & inflammation profile
Identify signs associated with gingivitis and periodontal disease risk.
Microbiome balance analysis
See how your beneficial and harmful oral bacteria compare.
Whole-body health signals
Explore microbial patterns associated with metabolic, cardiovascular, and inflammatory health.
Personalised recommendations
Practical guidance on oral hygiene, nutrition, and lifestyle habits to improve your microbiome over time.
Progress tracking
Retest periodically to monitor improvements and changes in your oral health.
Orvana combines the convenience of at-home collection with oral-health depth that standard checkups and generic DNA tests do not provide.
A synthesis of peer-reviewed literature across six major reviews, including one meta-analysis, showing that oral microbiome signatures can stratify disease risk before clinical symptoms appear.
6
Major peer-reviewed studies synthesised
1
Meta-analysis with highest level of evidence
7
Disease areas with consistent microbial findings
2,594
Subjects pooled across meta-analysed cohorts
The Chen et al. meta-analysis found specific oral microbial signatures carried a 9.5-fold odds ratio for esophageal squamous cell carcinoma — one of the strongest statistical links in the literature.
Thomas et al. (2021) establishes salivary microbial profiling as a validated, non-invasive source for monitoring diabetes, cardiovascular disease, and neurodegenerative conditions.
Rajasekaran et al. (2024) demonstrates that probiotics and oral hygiene interventions can shift the oral microbiome and reduce downstream disease risk.
Consistent microbial signatures across studies. Direct causality between dysbiosis and tissue damage.
Evidence: Very strong
P. gingivalis linked to arterial inflammation, endothelial dysfunction, and atherosclerosis.
Evidence: Strong
Oral dysbiosis correlates with insulin resistance and chronic low-grade systemic inflammation.
Evidence: Strong
Distinct microbial profiles associated with markedly increased cancer risk across pooled cohorts.
Evidence: Strong
Associations observed with rheumatoid arthritis and systemic inflammatory conditions.
Evidence: Moderate
Significant associations with inflammatory bowel disease and digestive microbiome cross-talk.
Evidence: Moderate
Early evidence that oral pathogens may contribute to neuroinflammation via systemic pathways.
Evidence: Emerging
Risk stratification, not diagnosis
Current literature consistently supports preventive monitoring and risk scoring — positioning Orvana as a Preventive Health Intelligence Platform.
Biologically plausible pathways
Li et al. (2022) and Bida et al. (2025) map clear mechanistic links between oral dysbiosis and cardiometabolic disease.
Strongest claims are quantifiable
The Chen meta-analysis establishes a precedent for oral microbiome-based risk prediction with statistical rigour (OR 9.50, 95% CI 5.89–15.29).
Sample collection
two minutes at home
Sequencing lab
700+ species profiled
AI analysis
12 risk signatures
Insight report
delivered in 48 hours
A four-step platform designed for home collection, lab-grade sequencing, AI analysis, and accessible digital reports.
Orvana has assembled lab partners, research collaboration pathways, and a Southeast Asia launch plan before full consumer release.
NovogeneAIT Genomics
MOU signed
Science Werks
MOU signed
A*STAR IHDP
Collaboration pathway
Singapore launch
In build
Orvana starts with high-margin direct-to-consumer test kits, then expands into recurring reports, corporate wellness, clinician channels, and enterprise datasets.
US$99
Affordable saliva-based oral microbiome test for Southeast Asian consumers.
25%
Repeat testing, personalised recommendations, and longitudinal microbiome tracking.
B2B
Corporate wellness, insurers, clinics, and public health partners.
Pre-seed close, lab agreements, and DTC launch, then SEA expansion, corporate wellness, and enterprise health system layers.
2025
2026
2027
A team spanning company-building, technology, healthcare operations, diagnostics, corporate wellness, and regional partnerships.
Gideon Agus Nuswantoro
Founder & CEO
Founder of Orvana Health with 20+ years across marketing, consumer business, operations, and venture portfolio management.
Sagit Hariaji
Co-founder & COO
Technology leader focused on enterprise systems, ERP, analytics, and bridging business needs with technical execution.
Carla Detera-Garganta, MD, DPPS
Co-founder & Head of Health
Healthcare and life sciences leader across Singapore and the Philippines, with experience in clinical operations and partnerships.
Sean Relampagos
CTO & VP of Engineering
Applied AI specialist with medtech expertise and repeat CTO experience, twice IBM certified and DeepLearning.AI certified. At Orvana, he leads engineering and owns the AI risk stratification models that turn raw sequencing data into clinician-ready reports.
Joel Balang
Marketing director, Malaysia
Adhi Ariyanto
Marketing director, Indonesia
Orvana's mission is to make precision oral health intelligence accessible to every person in Southeast Asia, not just those who can already afford premium care.
Affordable diagnostics
US$99 test kit priced at ~20–30% of comparable Western diagnostics, targeting sub-$70 per test by year 2.
Community health data
An anonymised SEA oral microbiome reference database for public health research via A*STAR IHDP collaboration.
Underserved populations
Phase 2 targets rural Malaysia, Indonesia, and the Philippines through subsidised outreach kits.
Orvana is pre-launch, so the voices here belong to peer-reviewed studies: paraphrased findings with their sources, not customer quotes.
“Pooled across 2,594 subjects, distinct oral microbial signatures carried a 9.5-fold odds ratio for esophageal squamous cell carcinoma — one of the strongest statistical links between the oral microbiome and systemic disease in the published literature.”
Chen, J.-C. et al. (2025) · Systematic review & meta-analysis
“Salivary microbial profiling is a validated, non-invasive source for monitoring diabetes, cardiovascular disease, and neurodegenerative conditions.”
Thomas, C. et al. (2021) · Review
“Probiotics and oral hygiene interventions can measurably shift the oral microbiome and reduce downstream disease risk.”
Rajasekaran, J. J. et al. (2024) · Review